Serveur d'exploration sur le lymphœdème

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Inter and intra-specific diversity of parasites that cause lymphatic filariasis

Identifieur interne : 004217 ( Main/Exploration ); précédent : 004216; suivant : 004218

Inter and intra-specific diversity of parasites that cause lymphatic filariasis

Auteurs : Samantha N. Mcnulty [États-Unis] ; Makedonka Mitreva [États-Unis] ; Gary J. Weil [États-Unis] ; Peter U. Fischer [États-Unis]

Source :

RBID : PMC:3801268

Descripteurs français

English descriptors

Abstract

Lymphatic filariasis is caused by three closely related nematode parasites: Wuchereria bancrofti, Brugia malayi and Brugia timori. These species have many ecological variants that differ in several aspects of their biology such as mosquito vector species, host range, periodicity, and morphology. Although the genome of B. malayi (the first genome sequenced from a parasitic nematode) has been available for more than five years, very little is known about genetic variability among the lymphatic dwelling filariae. The genetic diversity among these worms is not only interesting from a biological perspective, but it may have important practical implications for the Global Program to Eliminate Lymphatic Filariasis, as the parasites may respond differently to diagnostic tests and/or medical interventions. Therefore, better information on their genetic variability is urgently needed. With improved methods for nucleic acid extraction and recent advances in sequencing chemistry and instrumentation, this gap can be filled relatively inexpensively. Improved information on filarial genetic diversity may increase the chances of success for lymphatic filariasis elimination programs.


Url:
DOI: 10.1016/j.meegid.2012.11.002
PubMed: 23201850
PubMed Central: 3801268


Affiliations:


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Le document en format XML

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<p id="P2">Lymphatic filariasis is caused by three closely related nematode parasites:
<italic>Wuchereria bancrofti</italic>
,
<italic>Brugia malayi</italic>
and
<italic>Brugia timori</italic>
. These species have many ecological variants that differ in several aspects of their biology such as mosquito vector species, host range, periodicity, and morphology. Although the genome of
<italic>B. malayi</italic>
(the first genome sequenced from a parasitic nematode) has been available for more than five years, very little is known about genetic variability among the lymphatic dwelling filariae. The genetic diversity among these worms is not only interesting from a biological perspective, but it may have important practical implications for the Global Program to Eliminate Lymphatic Filariasis, as the parasites may respond differently to diagnostic tests and/or medical interventions. Therefore, better information on their genetic variability is urgently needed. With improved methods for nucleic acid extraction and recent advances in sequencing chemistry and instrumentation, this gap can be filled relatively inexpensively. Improved information on filarial genetic diversity may increase the chances of success for lymphatic filariasis elimination programs.</p>
</div>
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